Tsev > Kev Paub > Ntsiab lus
Diet Pills rau kev siv tshuaj
- Mar 28, 2018 -

1, Orlistat

Lub pancreatic lipase inhibitor, lipstatin, tau raug rho tawm los ntawm Streptomyces hauv xyoo 1987, tab sis vim 2 tsis ruaj ruaj cis-ob leeg bonds nyob rau hauv tus qauv, Roche tau txais ib qho kev ruaj khov orlistat los ntawm kev txo hydrogenation ntawm qhov chaw ntawm kev tuav nws cov qauv yooj yim. Nws tau pom zoo los ntawm FDA hauv 1999 los kho cov rog. Ntxiv nrog rau cov nyhav nyhav nyhav zoo, tab sis kuj tseem tuaj yeem txhim kho cov tshuaj antihypertensive tshuaj yooj yim tswj cov ntshav siab ntawm hypertensive cov neeg mob. Tsis tas li ntawd xwb, cov ntaub ntawv teev cov kab mob hauv cov ntshav tuaj yeem tswj cov ntshav qab zib thiab txo cov xwm txheej ntawm cov ntshav qab zib mellitus thaum lub cev poob. Orlistat, xws li gastrointestinal esterase inhibitor, cov inhibits cov lipase ntawm gastric lipase, pancreatic lipase thiab carboxyl ester, hinders qhov nqus ntawm fatty acid thiab ib leeg stearic acid hauv plab hnyuv ntxwm hlwb, li no txo qhov nqus ntawm 30% cov rog thiab nce excretion ntawm quav kom ua tiav lub hom phiaj ntawm qhov poob phaus.

2, Lorcaserin

1996 FDA tau tso cai thawj zaug rau kev kho cov rog rog poob phaus (femanyl) (dexfenfluramine), muaj lub cev tsis zoo, tab sis vim nws 5-ht2b thiab 5-HT2C reseptor tsis xaiv, ua rau mob plawv loj heev , tau raug tshem tawm ntawm lub nroog nyob rau hauv 1997. Yuav kom tsis txhob muaj lub plawv valve phiv tshuaj tiv thaiv los ntawm tus zoo siab 5-HT2B, Arena lub tsev lag luam ua lub tsev hloov ntawm cov fenfluramine, thiab c-1, c-6 ntawm lub benzene ntiv nplhaib tau tsim rau 1 benzodiazepine nuclei, thiab ces chlorine tau hloov rau C-3 ntsis ntawm trifluoromethyl. Nce nws cov kev xaiv rau 5-ht2c thiab tau txais Lorcaserin. Cov khoom no tau txais kev pom zoo los ntawm FDA rau lub Rau Hli Ntuj 2012 rau kev siv lub cev huab hwm coj Performance index (BMI) ≥27, thiab tsawg kawg yog 1 rog los yog rog cov neeg mob uas muaj teeb meem kev phaum ntawm kev kho mob ntxiv. Iorcaserin los ntawm kev xyum ua rau 5-HT2C reseptor nyob rau hauv hypothalamus, txo tsawg zog, satiety yog nce, tus mob 5-ht2b yog zam, thiab kev nyab xeeb ntawm tshuaj muaj zog. Feem ntau cov kev mob tshwm sim hauv cov neeg mob uas tsis muaj ntshav qab zib tau mob taub hau, kiv taub hau, qaug zog, xeev siab, ntuav ntub thiab cem quav. Feem ntau cov kev phiv tshuaj hauv diabetics muaj xws li hypoglycemia, mob taub hau, mob qhov mob, hnoos thiab qaug zog.


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